CURRENT ASPECTS OF DIAGNOSIS AND TREATMENT OF ATOPIC DISEASES COMPLICATED BY SECONDARY IMMUNODEFICIENCY

Aim, The study of clinicoimmunological features of current course of a topic diseases (AD) and design of effective etiopathogenic scheme of t reating AD complicated by secondary immunodeficiency (SID). Materials and methods. After comprehensive clinical, instrumental, x-ray, functi onal and bacteriological investigations 186 AD patients were divided i nto 4 groups: 25 patients untreated by immunomodulators (controls), 35 patients treated by diuciphone (200 g i.m, each other day for 12 days ), 83 patients treated by polyoxidonium (6 mg i.m. each other day for 12 days, a fetal course dose 30 mg, or 6 mg i.m. daily for 2 days then 6 mg each other day for 3 days then 6 mg twice a week for 14 days, a course close 45 mg), 33 patients received likopid (1 or 10 mg daily pe r os for 10 days or 10 mg daily for 10 days then 2 mg twice a week for 14 days). Results, A scheme of combined 3-staged treatment of AD comp licated by SID is suggested. Stage 1 - conventional treatment inhibiti ng aggravation of atopic reaction, improving functional condition of t he defense systems plus antiinfection therapy, immunomodulators. Stage 2 - primarily specific immunotherapy. Stage 3 - outpatient prophylaxi s of immunodeficiency and resistant forms of atopic reactions. Conclus ion, Combined staged pharmacological and immunological control of alle rgic inflammation and immunodeficiency is the main principle of contro l of AD with SID.