HEPATIC AND RENAL EXPRESSION OF SENESCENCE MARKER PROTEIN-30 AND ITS BIOLOGICAL SIGNIFICANCE

Authors
FUJITA T SHIRASAWA T INOUE H KITAMURA T MARUYAMA N
Citation
T. Fujita et al., HEPATIC AND RENAL EXPRESSION OF SENESCENCE MARKER PROTEIN-30 AND ITS BIOLOGICAL SIGNIFICANCE, Journal of gastroenterology and hepatology, 13, 1998, pp. 124-131
Citations number
32
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
Journal of gastroenterology and hepatology → ACNP
ISSN journal
08159319
Volume
13
Year of publication
1998
Supplement
S
Pages
124 - 131
Database
ISI
SICI code
0815-9319(1998)13:<124:HAREOS>2.0.ZU;2-7
Abstract
A novel rat hepatic protein was detected and isolated, the amount of w hich is downregulated in an androgen-independent manner with ageing. T his protein was designated as senescence marker protein-30 (SMP30). Se nescence marker protein-30 turned out to be identical to a hepatic cal cium-binding protein called regucalcin (RC). This review gives an over view of SMP30 in its structure, expression and possible physiological function(s). A hypothetical role of SMP30 in ageing and calcium homeos tasis is also discussed.