PURINE NUCLEOSIDE ANALOGS - 8 - N-2-ACETYLATION OF GUANINE DERIVATIVES

A method for the acetylation of the exocyclic amino group of guanine d erivatives has been developed. A series of N-2-acetylguanines was synt hesized by reacting of N-9(7)-alkoxyalkylguanines with an excess of ac etic anhydride in the presence of 4-dimethylaminopyridine. The method has been used successfully also for N-2-acetylation of guanosine and i ts 8-bromo derivative although in the latter case a partial substituti on of bromine for a hydroxy group at the position 8 of the heterocycle occurred.