ENDOSCOPIC DIAGNOSIS OF LOWER INTESTINAL LESIONS OF LEUKEMIA AND MALIGNANT-LYMPHOMA

There have been only a few endoscopic studies with respect to lower in testinal lesions of leukaemia and malignant lymphoma, although there h ave been many autopsy studies of these lesions. The aim of this study was to clarify these lesions using endoscopy. Colonoscopy was performe d on 11 of 341 patients with leukaemia and on 32 of 105 patients with malignant lymphoma for frequent diarrhoea, anal bleeding or abnormal f indings on barium enema examination, between April 1984 and September 1994. In eight of the 11 patients with leukaemia on whom endoscopy was performed, nine lesions were found; aphthoid ulcers, small ulcers or large tumours due to leukaemic infiltration were found in five, and co lorectal adenoma was found in only one patient. Antibiotic-associated haemorrhagic colitis or pseudomembranous colitis was found in one pati ent each. In 10 of the 32 patients with malignant lymphoma, 11 lesions were found. The following were found in one patient each: large lymph omatous tumours, a large lymphomatous ulcer, multiple small polypoid l esions, multiple lymphomatous polyposis; and colorectal cancer or aden oma in six patients. However, the autopsy findings in patients with bo th diseases were mostly pseudomembrane formation or ulcers due to fung al and/or bacterial infection. It is concluded that accurate endoscopi c diagnosis of lower intestinal lesions in patients with leukaemia or malignant lymphoma is essential for staging and treatment of these dis eases and for determining their prognosis. Most lesions in leukaemia a re aphthoid and small ulcers are due to leukaemic infiltration or anti biotics; most lesions in malignant lymphoma are elevated lesions such as cancer, adenoma or lymphomatous lesions as determined by endoscopy. This is in contrast to pseudomembrane formation or ulcers due to fung al and/or bacterial infection which are detected at autopsy.