T. Hanekom et al., ACTIVELY DEPOSITED CERAMIC LAYERS AS INSULATION ON THIN IMPLANTABLE ELECTRODE CONDUCTORS, South African journal of science, 94(7), 1998, pp. 310-311
The electrical and chemical insulation of thin platinum wires insulate
d with titanium dioxide or alumina was investigated. These non-conduct
ing layers were deposited onto wire surfaces using conducting material
s in a unique active sputtering process and were evaluated Sor possibl
e use as insulation on implantable electrode conductors. The mechanica
l properties of the layers were found to be appropriate for the applic
ation, although it was not conclusively established whether these ultr
a-thin coatings would provide satisfactory biocompatibility. In vitro
evaluation indicated pinholes in the lavers, which permitted contact b
etween the underlying metal and the ions iir a saline solution. In viv
o evaluation revealed slight inflammatory; responses, probably indicat
ive of impurities in the ceramic layers.