Mr. Jackson et al., HEMOSTATIC EFFICACY OF A FIBRIN SEALANT DRESSING IN AN ANIMAL-MODEL OF KIDNEY INJURY, The journal of trauma, injury, infection, and critical care, 45(4), 1998, pp. 662-665
Objective: The purpose of this study is to determine the hemostatic ef
ficacy of a fibrin sealant dressing compared with a standard collagen
control dressing in an animal model of kidney injury. Methods: Twenty
adult male Sprague-Dawley rats were administered general anesthesia an
d underwent partial nephrectomy with heparin anticoagulation (300 U/kg
intravenous). Treatment of the cut surface of the kidney was randomiz
ed to three groups: group I, no hemostatic agent; group II, collagen d
ressing; and group III, fibrin sealant dressing. Results: Blood loss w
as significantly less in group III (3.39 +/- 0.63 mL) than in group I
(8.64 +/- 2.26 mL) and group II (8.63 +/- 1.72 mL; p < 0.001). The per
centage decrease in the mean arterial pressure was significantly less
in group III (34.09 a 15.58%) than in group I (59.66 +/- 16.19%) and g
roup II (60.35 +/- 15.66%; p = 0.015), Conclusion: Fibrin sealant dres
sings provide effective hemostasis and are superior to collagen dressi
ngs in an animal model of kidney injury. Additional development of fib
rin sealant dressings for potential clinical use is warranted.