HEMOSTATIC EFFICACY OF A FIBRIN SEALANT DRESSING IN AN ANIMAL-MODEL OF KIDNEY INJURY

Citation
Mr. Jackson et al., HEMOSTATIC EFFICACY OF A FIBRIN SEALANT DRESSING IN AN ANIMAL-MODEL OF KIDNEY INJURY, The journal of trauma, injury, infection, and critical care, 45(4), 1998, pp. 662-665
Citations number
22
Categorie Soggetti
Emergency Medicine & Critical Care
Volume
45
Issue
4
Year of publication
1998
Pages
662 - 665
Database
ISI
SICI code
Abstract
Objective: The purpose of this study is to determine the hemostatic ef ficacy of a fibrin sealant dressing compared with a standard collagen control dressing in an animal model of kidney injury. Methods: Twenty adult male Sprague-Dawley rats were administered general anesthesia an d underwent partial nephrectomy with heparin anticoagulation (300 U/kg intravenous). Treatment of the cut surface of the kidney was randomiz ed to three groups: group I, no hemostatic agent; group II, collagen d ressing; and group III, fibrin sealant dressing. Results: Blood loss w as significantly less in group III (3.39 +/- 0.63 mL) than in group I (8.64 +/- 2.26 mL) and group II (8.63 +/- 1.72 mL; p < 0.001). The per centage decrease in the mean arterial pressure was significantly less in group III (34.09 a 15.58%) than in group I (59.66 +/- 16.19%) and g roup II (60.35 +/- 15.66%; p = 0.015), Conclusion: Fibrin sealant dres sings provide effective hemostasis and are superior to collagen dressi ngs in an animal model of kidney injury. Additional development of fib rin sealant dressings for potential clinical use is warranted.