Sjs. Flora et al., EFFECTS OF ZINC SUPPLEMENTATION DURING CHELATING AGENT ADMINISTRATIONIN CADMIUM INTOXICATION IN RATS, Journal of applied toxicology, 18(5), 1998, pp. 357-362
The concomitant administration of zinc during chelation of cadmium (Cd
) with meso-2,3-dimercaptosuccinic acid (DMSA) or calcium trisodium di
ethylenetriamine penta-acetic acid (DTPA) was investigated in male rat
s subchronically exposed to Cd, The results suggest that the administr
ation of zinc alone after cadmium exposure does not elicit any protect
ive effects, However, when supplemented during treatment with DTPA it
produced a significant turnover in the altered biochemical variables a
nd a depletion of Cd concentration in liver and kidneys. Cadmium-induc
ed elevated hepatic metallothionein (MT) contents remained practically
unaltered on Zn-DTPA administration, but there was a significant incr
ease in renal MT levels compared to rats administered Cd-DTPA or Cd al
one. (C) 1998 John Wiley & Sons, Ltd.