STRUCTURE OF DNA TOPOISOMERASES

Authors
BERGER JM
Citation
Jm. Berger, STRUCTURE OF DNA TOPOISOMERASES, Biochimica et biophysica acta, N. Gene structure and expression, 1400(1-3), 1998, pp. 3-18
Citations number
81
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta, N. Gene structure and expression → ACNP
ISSN journal
01674781
Volume
1400
Issue
1-3
Year of publication
1998
Pages
3 - 18
Database
ISI
SICI code
0167-4781(1998)1400:1-3<3:SODT>2.0.ZU;2-F
Abstract
Over the last several years topoisomerases have finally begun to yield to high-resolution structural studies. These models have greatly aide d our understanding of the mechanisms of topoisomerase catalysis and d rug interactions. This review will cover advances in the structural bi ology of topoisomerases and discuss their implications for topoisomera se function. 0167-4781/98/$ - see front matter (C) 1998 Elsevier Scien ce B.V. All rights reserved.