VACCINATION WITH RECOMBINANT PARASITE SURFACE-ANTIGEN-2 FROM LEISHMANIA-MAJOR INDUCES A TH1 TYPE OF IMMUNE-RESPONSE BUT DOES NOT PROTECT AGAINST INFECTION
A. Sjolander et al., VACCINATION WITH RECOMBINANT PARASITE SURFACE-ANTIGEN-2 FROM LEISHMANIA-MAJOR INDUCES A TH1 TYPE OF IMMUNE-RESPONSE BUT DOES NOT PROTECT AGAINST INFECTION, Vaccine, 16(20), 1998, pp. 2077-2084
Citations number
41
Categorie Soggetti
Veterinary Sciences",Immunology,"Medicine, Research & Experimental
Vaccination with the native Parasite Surface Antigen 2 of Leishmania m
ajor with Corynebacterium parvum as adjuvant protects mice from leishm
aniasis through a Th1 mediated response. Here we show that vaccination
with a recombinant form of this protein, purified from Escherichia co
li and administered in iscoms or with C. parvum as adjuvant, does not
induce protective immunity despite the induction of Th1 responses. The
results suggest that protective immunity depends on the ability of th
e vaccinating antigen to induce Th1-like T cells with ability to be re
called by infection, Therefore, the conformation of antigens may play
a more major role fop the induction of T cell mediated immunity than o
riginally considered. (C) 1998 Elsevier Science Ltd. All rights reserv
ed.