M. Castrogago et al., INDICATORS OF HYPOXIA IN CEREBROSPINAL-FLUID OF HYDROCEPHALIC CHILDREN WITH SUSPECTED SHUNT MALFUNCTION, Child's nervous system, 9(5), 1993, pp. 275-277
We used high performance liquid chromatography to determine the concen
tration of purine metabolites in the cerebrospinal fluid of three hydr
ocephalic children with a history of shunt malfunction. Hypoxanthine a
nd xanthine levels were high in comparison with controls. We consider
these purines to be valuable indicators of disturbance of neuronal met
abolism following the sustained rise in intracranial pressure caused b
y shunt valve malfunction.