M. Tamura et al., DELAYED BRAIN HEMORRHAGE ASSOCIATED WITH PROPHYLACTIC WHOLE-BRAIN IRRADIATION FOR PEDIATRIC MALIGNANT BRAIN-TUMOR - A CASE-REPORT, Child's nervous system, 9(5), 1993, pp. 300-301
Intraparenchymal hemorrhage in the left frontal lobe suddenly occurred
in a 7-year-old girl who had undergone partial removal of an undiffer
entiated brain stem glioma and received craniospinal (30 Gy) and poste
rior fossa booster (20 Gy) irradiation at the age of 20 months. The br
ain hemorrhage was thought to be delayed irradiation effect. Follow-up
neuro-imaging at age 9 years showed two more small occult chronic and
subacute hemorrhages in the brain. The possibility of repeated hemorr
hage as a delayed reaction to brain irradiation is emphasized.