POSTOPERATIVE COURSE OF COLLAGEN AND BONE METABOLISM IN PATIENTS WITHTNR

Introduction: This study investigated the influence of concentration a nd activity of several markers of the collagen and bone metabolism and their impact on ingrowth of non-cemented total hip arthroplasty. Meth ods: 40 patients underwent an implantation of a ABG-prosthesis. Bevor surgery and 1, 2, 12 and 24 weeks after it serum concentrations of PIC P, ICTP, IGF-1, ON, b-AP, Calcium, Phosphate, GPT and Creatinin were m easured and a collagen ratio(CQ) was calculated. Results: PICP decreas ed until Ist week, encreased at 2nd week and decreased again after tha t time. ICTP increased significantly in Ist week, reached a maximum in 2nd week and decreased after that. b-AP decreased in Ist week but enc reased after that time, IGF-1 and ON decreased significantly after sur gery but increased later. Calcium and Phosphate always showed normal v alues. CQ decreased in Ist week in males (45%) and females (60%), but increased later on. Conclusion: These markers investigated made it pos sible to estimate the osteointegration of non-cemented total hip arthr oplasty and confirm radiologic and histomorphometric results of the li terature.