DIFFERENT RESPONSE TO INFLAMMATION OF THE MULTIPLE MESSENGER-RNAS OF RAT N-ACETYLGLUCOSAMINYLTRANSFERASE-I WITH VARIABLE 5'-UNTRANSLATED SEQUENCES

Authors
FUKADA T KIOKA N NISHIU J SAKATA S SAKAI H YAMADA M KOMANO T
Citation
T. Fukada et al., DIFFERENT RESPONSE TO INFLAMMATION OF THE MULTIPLE MESSENGER-RNAS OF RAT N-ACETYLGLUCOSAMINYLTRANSFERASE-I WITH VARIABLE 5'-UNTRANSLATED SEQUENCES, FEBS letters, 436(2), 1998, pp. 228-232
Citations number
22
Categorie Soggetti
Biology,"Cell Biology",Biophysics
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
436
Issue
2
Year of publication
1998
Pages
228 - 232
Database
ISI
SICI code
0014-5793(1998)436:2<228:DRTIOT>2.0.ZU;2-E
Abstract
We found that there are at least five subclasses of N-acetylglucosamin yltransferase I(GnT-I; EC 2.4.1.101) mRNA with different 5 '-untransla ted regions in rat brain. These five subclasses were also expressed in many tissues with distinct tissue-specific patterns. Moreover, they w ere regulated differently in response to acute-phase inflammation, The expression of the most abundant subclass of GnT-I mRNA in rat liver d ecreased 2.5-fold in response to inflammation, concomitantly with a si gnificant decrease in the total amount of GnT-I mRNA, In contrast, one of the minor subclasses of GnT-I mRNA was induced 10-fold by inflamma tion. (C) 1998 Federation of European Biochemical Societies.