ENHANCEMENT AND INHIBITION OF SNAKE-VENOM PHOSPHODIESTERASE ACTIVITY BY LYSOPHOSPHOLIPIDS

Lysophospholipids are liberated during venomous action. In this study se demonstrated that lysophosphatidyl choline (LPC) of various acyl ch ains enhances considerably the activity of snake venom phosphodiestera se (PDE). Lysophosphatidic acid (LPA) and its cyclic form (cLPA), on t he other hand, were found to inhibit this enzyme in a non-competitive (LPA) or competitive (cLPA) manner. Both of these activities may contr ibute to the progression and subsidence of the poisoning profile. PDE from cellular origin was not substantially affected by any of the abov e lysophospholipids. (C) 1998 Federation of European Biochemical Socie ties.