EQUILIBRIUM CONTROL IN BROMOMETHYLATION - AN EXPEDIENT ROUTE TO AMINO-3-(3-HYDROXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID (AMPA)

Authors
BEGTRUP M SLOK FA
Citation
M. Begtrup et Fa. Slok, EQUILIBRIUM CONTROL IN BROMOMETHYLATION - AN EXPEDIENT ROUTE TO AMINO-3-(3-HYDROXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID (AMPA), Synthesis, (9), 1993, pp. 861-863
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
9
Year of publication
1993
Pages
861 - 863
Database
ISI
SICI code
0039-7881(1993):9<861:ECIB-A>2.0.ZU;2-S
Abstract
The excitatory amino acid amino-3-(3-hydroxy-5-methylisoxazol-4-yl)pro pionic acid (AMPA) has been prepared in gram quantities in 42 % total yield by a three-step procedure from 3-hydroxy-5-methylisoxazole. It i s shown how bromomethylation may be optimized through control of the i nvolved equilibria and how N-protecting methoxymethyl groups can be re moved.