A COMPLEX CHROMOSOMAL REARRANGEMENT DETECTED PRENATALLY AND STUDIED BY FLUORESCENCE IN-SITU HYBRIDIZATION

We report of case of a complex chromosomal rearrangement detected pren atally and studied with traditional banding methods and fluorescence i n situ hybridization. The combination of these techniques showed that four chromosomes were involved in the translocation. Nine breakpoints were proposed to explain these results. Some of the findings could onl y be detected with fluorescence in situ hybridization, demonstrating t he usefulness of this technique in characterizing chromosomal abnormal ities that would otherwise be difficult to interpret correctly with cl assical cytogenetics alone.