GENETIC DATA OBTAINED FOR 2 CHINESE HAN POPULATIONS WITH A QUADRUPLEXFLUORESCENT STR TYPING SYSTEM (HUMVWA, HUMTH01, D21S11 AND HPRT)

DNA typing of four tetrameric repeat loci (HUMVWA, HUMTH01, D21S11 and HPRT) was carried out in a Chinese Han population from Shanghai (East China) and one from Guangzhou (South-East China) using a quadruplex P CR amplification and detection of the fluorescent-labeled alleles on t he ALF DNA sequencer. All loci were in accordance with Hardy-Weinberg equilibrium except for D21S11 in the Guangzhou population. A test for population differentiation showed no statistical difference in the all ele frequency distribution between the two populations. Comparison of the allele frequency data with other Chinese Han populations from Nort h and South-West China for the STR loci HUMVWA and HUMTH01 revealed he terogeneity between Northern Chinese Han and Southern Chinese Han, whi ch is in accordance with previous studies on the basis of protein mark ers.