SERUM AND URINE FLUORIDE CONCENTRATION - RELATIONSHIPS TO AGE, SEX AND RENAL-FUNCTION IN A NONFLUORIDATED POPULATION

Serum and urine fluoride levels were determined in 250 healthy subject s (15-90 years, 122 men and 128 women) residing in Catalonia, Spain, a nd in 150 patients (20-81 years, 84 men and 66 women) with chronic ren al failure undergoing regular dialysis treatment, living in the same g eographical area, to determine normal range and to investigate its rel ationships to age, sex and renal function. Serum and urine fluoride we re determined by a fluoride ion specific electrode system. Mean (+/-S. D..) serum fluoride concentration was 17.5 +/- 9.5 mu g/l, ranging fro m 1 to 47 mu g/l, in the control group and 58 +/- 31 mu g/l, ranging f rom 28 to 185 mu g/l, in renal patients. Urine fluoride concentration in the healthy group was 671 +/- 373 mu g/24 h, ranging from 156 to 19 00 mu g/24 h. Fluoride status in the patient group was significantly g reater than the control group. There was significant correlation betwe en serum fluoride and age. No sex related difference was found. (C) 19 98 Elsevier Science B.V. All rights reserved.