DNA-DAMAGE CHECKPOINT IN BUDDING YEAST

Eukaryotic cells have evolved a network of control mechanisms, known a s checkpoints, which coordinate cell-cycle progression in response to internal and external cues. The yeast Saccharomyces cerevisiae has bee n invaluable in dissecting genetically the DNA damage checkpoint pathw ay. Recent results on posttranslational modifications and protein-prot ein interactions of some key factors provide new insights into the arc hitecture of checkpoint protein complexes and their order of function.