BACKGROUND AND OBJECTIVE: Photodynamic therapy with tin ethyl etiopurp
urin (SnET2) was evaluated as a treatment modality for rat corneal neo
vascularization.MATERIALS AND METHODS: Escalating light doses at 664 n
m were applied focally to corneal neovascularization in rats 10 minute
s following an intravenous injection of SnET2 using a low-power diode
laser. Controls consisted of light-only and drug-only treatments. Clin
ical, angiographic, and histopathologic evaluations were performed on
the animals up to 28 days after drug and/or light treatment. RESULTS:
A drug and light dose-response was seen in producing neovessel closure
. In animals treated with SnET2 and the highest light dose (25 J/cm(2)
), all eyes showed occlusion at every follow-up evaluation up to 28 da
ys. Control eyes demonstrated progressive disease at all time points.
CONCLUSIONS: Photodynamic therapy appears to be safe and effective for
eliciting prolonged (> 28 days) occlusion of corneal neovascularizati
on in the rat model with minimal side effects and good clinical outcom
es.