GOPTEN (TRANDOLAPRIL) TREATMENT OF CHRONIC CARDIAC-FAILURE IN PATIENTS WITH ISCHEMIC-HEART-DISEASE

Aim. To investigate clinical efficacy of angiotensin-converting enzyme inhibitor trandolapril and its effects on myocardial function. Materi als and method. 20 patients with ischemic heart disease (IHD) aged 33- 74 years with chronic cardiac failure NYHA class II-IV. 4 of them surv ived myocardial infarction. In addition to the routine tests, the pati ents underwent echocardiography, radionuclide ventriculography. Trando lapril was given once a day for 28 days in a dose 2 mg, then a repeat examination was performed Results. Trandolapril produced a subjective effect in 80% of patients; There was also improvement of hemodynamic p arameters, an increase in the ejection fraction, sensitivity to nitrog lycerin, decline of asynchronia. The drug was well tolerated. Conclusi on. Trandolapril (gopten) is effective in IHD patients with chronic ca rdiac failure.