TUBULOINTERSTITIAL NEPHRITIS ASSOCIATED WITH UVEITIS

Acute tubulointerstitial nephritis associated with uveitis is an infre quent entity. The etiology is unknown but in its pathogenesis, cellula r immunological mechanisms have been implicated. We describe of a thir teen-year-old girl who presented with a constitutional syndrome and ac ute renal failure (serum creatinine 2.2 mg/dl) with a later developmen t of an anterior uveitis. The pathology showed an acute tubulointersti tial nephritis with a predominant T lymphocytic infiltrate. The immuno fluorescence was negative. The patient was treated biochemical with co rticosteroids which produced dramatic clinical and biochemical improve ment. We emphasize the importance of diagnosing this syndrome, the rol e of kidney biopsy, and the successful steroid treatment.