SYNTHETIC IONOPHORES - PART 17 - SYNTHESIS OF ETHER-AMINE-AMIDE BASEDM-CYCLOPHANES - A SEARCH FOR PB2+ SELECTIVE IONOPHORES

m-Cyclophanes 3, 4, and 5 possessing two ether oxygen, two amide, one NH and a pi-system, an optimal combination of ligating sites for selec tive Pb2+ binding, have been synthesized by condensations of diethylen etriamine, 3,3'-diaminodipropylamine and 1,3-diaminopropane with 1,3-b is(ethoxycarbonylmethoxy) benzene (6) formed by the PTC reaction of re sorcinol and ethyl chloroacetate. Ionophores 3-5 induced cation extrac tion/transport could not be studied due to their insolubility in CHCl3 /CH2Cl2 and solubility in water, but (CNMR)-C-13 titrations of 4 with metal ions point to its binding preferences for Ag+ and Pb2+ over alka li/alkaline earth cations.