BABOON HUMAN HOMOLOGIES EXAMINED BY SPECTRAL KARYOTYPING (SKY) - A VISUAL COMPARISON/

Baboon (Papio hamadryas) metaphase chromosomes were analyzed using spe ctral karyotyping (SKY), a technique combining fluorescence microscopy , CCD-imaging, and Fourier spectroscopy. Results from a comparison of SKY analyses using probes derived from human chromosomes on baboon met aphases were consistent with the majority of comparative gene mapping data between the two species. These data were also compatible with ear lier studies comparing macaque and human chromosomes. Human (HSA) chro mosome 2 was homologous to baboon (PHA) chromosomes 12 (HSA 2q) and 13 (HSA 2p), whereas three baboon chromosomes corresponded to two differ ent human chromosomes: PHA 3 to HSA 7 and HSA 21, PHA 7 to HSA 14 and HSA 15, and PHA 10 to HSA 20 and HSA 22. These results support the ret ained synteny between the Hominidae and Cercopithecidae genomes.