3 DIABETIC CASES OF ACUTE DIZZINESS DUE TO INITIAL ADMINISTRATION OF VOGLIBOSE

We observed 3 diabetic patients,vith intolerable dizziness followed by nausea and vomiting immediately after an initial administration of th e alpha-glucosidase inhibitor, voglibose, These symptoms did not recur after discontinuation of the drug. Adverse effects as observed in the se cases have not been reported previously. Since the 3 patients were relatively old (average age, 72 years old) and had various degrees of micro- and macroangiopathies, these side effects may have been associa ted with increased micro- and macrocirculatory disturbances in their c entral nervous systems through alpha-glucosidase inhibition of this ag ent.