DETERMINATION OF BENZYDAMINE HYDROCHLORIDE IN SERUM AND URINE BY USING A BENZYDAMINE ION-SELECTIVE PIEZOELECTRIC SENSOR

An ion-selective piezoelectric sensor (ISP) was developed for the rapi d determination of benzydamine hydrochloride in serum and urine. The I SP device was fabricated by coating a PVC membrane containing benzydam ine phosphotungstate on one electrode of a thickness-shear mode piezoe lectric quartz crystal. The selective adsorption of benzydamine ion ac ross the membrane caused a decrease in the oscillating frequency; also the logarithm of the frequency shift has a linear relation to the log arithm of the concentration of benzydamine over the ranges 2x10(-7) - 8x10(-3) M with a detection limit of 2.0x10(-7) M at pH 7.0. Influenci ng factors were investigated and optimized. The results for real sampl es obtained by the proposed method were in agreement with those by the conventional non-aqueous titrimetric method.