Wf. Li et al., DETERMINATION OF BENZYDAMINE HYDROCHLORIDE IN SERUM AND URINE BY USING A BENZYDAMINE ION-SELECTIVE PIEZOELECTRIC SENSOR, Analytical sciences, 14(5), 1998, pp. 955-960
An ion-selective piezoelectric sensor (ISP) was developed for the rapi
d determination of benzydamine hydrochloride in serum and urine. The I
SP device was fabricated by coating a PVC membrane containing benzydam
ine phosphotungstate on one electrode of a thickness-shear mode piezoe
lectric quartz crystal. The selective adsorption of benzydamine ion ac
ross the membrane caused a decrease in the oscillating frequency; also
the logarithm of the frequency shift has a linear relation to the log
arithm of the concentration of benzydamine over the ranges 2x10(-7) -
8x10(-3) M with a detection limit of 2.0x10(-7) M at pH 7.0. Influenci
ng factors were investigated and optimized. The results for real sampl
es obtained by the proposed method were in agreement with those by the
conventional non-aqueous titrimetric method.