EARLY ANALYSIS OF VIREMIA AND CLINICAL-TESTS IN PATIENTS WITH EPIDEMIC HEMORRHAGIC-FEVER

We analysed the early viremia and clinical tests in 82 patients with e pidemic hemorrhagic fever (EHF). The results showed that the changes i n viremia and clinical tests are related to the severity of the diseas e and prognosis. Higher concentrations of the virus in infected patien ts might cause a more unfavourable prognosis and more abnormalities in clinical tests. CK-MB, SGOT, SGPT, serum creatinine and urea nitrogen contents increased markedly, while serum total protein, albumin and c alcium contents decreased markedly, indicating that the heart, liver a nd kidney in EHF patients were severely damaged. Markedly increased WB C and monocytes showed that the patients were seriously infected. Plat elet count, antithrombin-III and plasminogen decreased markedly, demon strating that there were marked changes in the coagulation-anticoagula tion and fibrinolytic system of the EHF patients. Changes in RBC, Hb a nd HCT contents indicated that the blood in the EHF patients had a hig her concentration. This study gives further evidence that EHFV plays a n important role in the pathogenesis of EHF.