SYNTHESIS AND SURFACE CHARACTERIZATION OF FUNCTIONALIZED POLYLACTIDE COPOLYMER MICROPARTICLES

Citation
Ke. Gonsalves et al., SYNTHESIS AND SURFACE CHARACTERIZATION OF FUNCTIONALIZED POLYLACTIDE COPOLYMER MICROPARTICLES, Biomaterials, 19(16), 1998, pp. 1501-1505
Citations number
15
Categorie Soggetti
Materials Science, Biomaterials","Engineering, Biomedical
Journal title
ISSN journal
01429612
Volume
19
Issue
16
Year of publication
1998
Pages
1501 - 1505
Database
ISI
SICI code
0142-9612(1998)19:16<1501:SASCOF>2.0.ZU;2-G
Abstract
Microparticles of poly(lactide) (PLac) and its copolymers with the ami no acids, serine (P(Lac-Ser)), and aspartic acid (P(Lac-Asp)), respect ively, were synthesized using the solvent evaporation microemulsion te chnique. Poly(vinyl alcohol) (PVA) was added as a non-ionic surfactant to stabilize the particles. The particle sizes are in the range of 20 0 nm. The surface of the particles was characterized by FTIR transmiss ion spectroscopy under evacuation at room temperature and at 200 degre es C. Hydroxy groups originating from PVA exist on the surfaces of the particles and they were observed at 3506 cm(-1). Free hydroxy groups originating from the serine residue pendant to the copolymer P(Lac-Ser ) backbone were observed at 3396 cm(-1). Also, free carboxylic acid gr oups pendant to the copolymer P(Lac-Asp) backbone, originating from th e aspartic acid residue, were observed at 3387 cm(-1). The appearance of the free hydroxy or carboxylic acid groups in the IR spectra also s howed that these hydrophilic functional groups moved to the surface of the particles in the process of microemulsion. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.