In order to improve the administration of drugs for all pathology of t
he oral cavity, we have developed an intraoral controlled release deli
vering system, permitting to reach high enough local concentrations fo
r desirable therapeutic effect with minimal side effects. We have form
ulated tablets of 200 mg intended to be fixed on a tooth. These tablet
s resist food and drink attacks. The tablets we elaborated have a gran
ular matrix composed of hydroxyapatite, ethyl cellulose and Eudragit((
R)). Zinc sulfate is used as the first model of an active drug, it has
a therapeutic effect on buccal mucous. Profiles of continuous in-vitr
o drug release in distilled water at 37 degrees C show that zinc sulfa
te release by the matrix structure for the different tablet formulatio
ns is regulated by the proportions of the different components. (C) 19
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