A NEW METHOD FOR THE SYNTHESIS OF N-3-ALKYLATED ANALOGS OF 5-FLUOROURACIL

Authors
KOZAI S FUKAGAWA T MARUYAMA T
Citation
S. Kozai et al., A NEW METHOD FOR THE SYNTHESIS OF N-3-ALKYLATED ANALOGS OF 5-FLUOROURACIL, Journal of the Chemical Society. Perkin transactions. I (Print), (19), 1998, pp. 3145-3146
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I (Print) → ACNP
ISSN journal
0300922X
Issue
19
Year of publication
1998
Pages
3145 - 3146
Database
ISI
SICI code
0300-922X(1998):19<3145:ANMFTS>2.0.ZU;2-I
Abstract
5-Fluorouracil has been converted to 5-chloro-5-fluoro-6-methoxy-5, 6- dihydrouracil 1. Compound 1 was condensed with alcohols using a Mitsun obu reaction to give N-3-alkylated products 2a,b, which were hydrogena ted in the presence of palladium on activated carbon to afford N-3-alk yl-5-fluorouracils 3a,b.