SYNTHESES OF NOVEL PIPERIDIN-4-YLPHOSPHINIC ACID, AND PIPERIDIN-4-YLPHOSPHONIC ACID ANALOGS OF THE INHIBITORY NEUROTRANSMITTER 4-AMINOBUTYRIC ACID (GABA)

Authors
KEHLER J EBERT B DAHL O KROGSGAARDLARSEN P
Citation
J. Kehler et al., SYNTHESES OF NOVEL PIPERIDIN-4-YLPHOSPHINIC ACID, AND PIPERIDIN-4-YLPHOSPHONIC ACID ANALOGS OF THE INHIBITORY NEUROTRANSMITTER 4-AMINOBUTYRIC ACID (GABA), Journal of the Chemical Society. Perkin transactions. I (Print), (19), 1998, pp. 3241-3243
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I (Print) → ACNP
ISSN journal
0300922X
Issue
19
Year of publication
1998
Pages
3241 - 3243
Database
ISI
SICI code
0300-922X(1998):19<3241:SONPAA>2.0.ZU;2-5
Abstract
Piperidin-4-ylphosphinic acid, methyl(piperidin-4-yl)phosphinic acid a nd piperidin-4-ylphosphonic acid analogues of the GABAA agonist piperi din-4-ylcarboxylic acid (isonipecotic acid) were synthesised. The acid groups were introduced using a sequential Pudovik addition followed b y a Barton deoxygenation procedure and finally followed by acidic hydr olysis. The mild and efficient procedure gave the target amino acids i n good yields.