SILICA-BASED PACKING MATERIALS FOR PREP HPLC, SFC AND SMB

Silica-based packings for preparative HPLC, SFC and SMB are today manu factured with high batch to batch reproducibility and with analytical performance. Mechanical strength, loadability and chemical stability a re, among others, the parameters which influence to a large extent a p roblem-free process and good total economy in the purification step. I n this paper these properties will be described together with the manu facturing methods for spherical, totally porous particles and the chem ical methods for surface modification of the particles.