This paper evaluates syphilis seroprevalence among women at the time o
f delivery and aims to identify weaknesses in antenatal syphilis contr
ol. In a cross-sectional study, ail mothers delivering at the largest
maternity in Kingston between 13 March 1996 and 3 April 1996 were eval
uated using a questionnaire and antenatal records. Maternal sera as we
ll as sera from infants born to syphilis seroreactive mothers were tes
ted with Toluidine Red Unheated Serum Test (TRUST). Maternal TRUST-rea
ctive sera were tested with Microhemagglutination for Treponema pallid
um (MHA-TP). Of the 504 women evaluated, 482 (95.6%) had received ante
natal care (ANC); 34 (6.7%) were syphilis seroreactive at delivery: 14
(77.8%) of 18 women found sero(+) during pregnancy; four (1.4%) of 283
women with negative antenatal syphilis serology; and 16 (7.9%) of 203
women who had no antenatal syphilis result. Five (27.8%) of the 18 wo
men who were found sero(+) during pregnancy had received three benzath
ine penicillin injections before delivery, six (33.3%) women had recei
ved no antenatal treatment. Syphilis seroreactivity was 22.7% in women
who had not received ANC versus 6.0% among women who had (OR: 4.6, p=
.01). Syphilis seroreactivity at delivery was associated with a histor
y of stillbirth (p=.02). Of 37 newborns with syphilis seroreactive mot
hers, 21 (56.7%) were TRUST(+). Both pregnant women and ANC providers
must be made aware of the need for improved antenatal syphilis control
. Results of syphilis screening should be available before the mother
leaves the ANC clinic to avoid poor follow-up, the first injection sho
uld be given the same day to seroreactors. Free testing should be offe
red when required. Women should be tested early in pregnancy and again
before delivery.