RISK OF RECURRENT SPONTANEOUS-ABORTION, CIGARETTE-SMOKING, AND GENETIC POLYMORPHISMS IN NAT2 AND GSTM1

Authors
MENDOLA P MOYSICH KB FREUDENHEIM JL SHIELDS PG SCHISTERMAN EF GRAHAM S VENA JE MARSHALL JR AMBROSONE CB
Citation
P. Mendola et al., RISK OF RECURRENT SPONTANEOUS-ABORTION, CIGARETTE-SMOKING, AND GENETIC POLYMORPHISMS IN NAT2 AND GSTM1, Epidemiology, 9(6), 1998, pp. 666-668
Citations number
17
Categorie Soggetti
Public, Environmental & Occupation Heath
Journal title
Epidemiology → ACNP
ISSN journal
10443983
Volume
9
Issue
6
Year of publication
1998
Pages
666 - 668
Database
ISI
SICI code
1044-3983(1998)9:6<666:RORSCA>2.0.ZU;2-R
Abstract
Maternal smoking increases the risk of spontaneous abortion. Polymorph ic N-acetyltransferase (NAT2) and glutathione S-transferase (GSTM1) af fect metabolism of some mutagens found in tobacco smoke. Genotypes and smoking were studied in women with at least two spontaneous abortions (N = 32) and those with at least two livebirths (N = 179). Smoking sl ightly increased risk (odds ratio = 1.3; 95% confidence interval = 0.6 -2.9), but NAT2 and GSTM1 did not. NAT2 or GSTM1 polymorphisms did not appreciably modify smoking-related risk.