AGE-SPECIFIC VARIATION IN ANEUPLOIDY INCIDENCE AMONG BIOCHEMICAL SCREENING PROGRAMS

OBJECTIVE: Our purpose was to compare the observed age-related inciden ce of Down syndrome in two large screening programs with the commonly quoted incidences used in biochemical screening programs. STUDY DESIGN : Data from two large prenatal screening programs were stratified in 5 -year age groups. The age-related incidence of Down syndrome was compa red with the commonly used incidence as reported by Cuckle. RESULTS: N o significant differences were found in age-related incidences of Down syndrome in any age group between the screening groups or among women ages 15 through 29 in any of the three groups. However, for women 30 to 34 and greater than or equal to 40 years old, a trend was noted tow ard a higher incidence in the screening groups. For women ages 35 to 3 9, the observed incidence was significantly greater in the screening g roups compared with the data of Cuckle. CONCLUSION: Our data suggest a n underascertainment in Down syndrome risk built into the Cuckle model , particularly in high-risk patients.