MATRIX-ASSISTED FILAMENT DESORPTION IONIZATION MASS-SPECTROMETRY/

We describe an improved sample preparation method for pulsed filament desorption-ionization mass spectrometry. Samples were deposited in the presence of an excess of liquid or solid matrices. Especially with li quid matrices such as glycerol, this allowed stable and reproducible i on production for a variety of compounds, including biomolecules and s ynthetic polymers. Substances with molecular weights up to 3000 Da cou ld be desorbed, ionized, and detected by time-of-flight mass spectrome try. (J Am Sec Mass Spectrom 1998, 9, 1226-1228) (C) 1998 American Soc iety for Mass Spectrometry.