STUDIES ON THE ANTI-PHOSPHOLIPASE-A(2) AND ANTIINFLAMMATORY ACTIVITIES OF A UTEROGLOBIN FRAGMENT AND RELATED PEPTIDES

Authors
MARASTONI M SCARANARI V ROMUALDI P DONATINI A FERRI S TOMATIS R
Citation
M. Marastoni et al., STUDIES ON THE ANTI-PHOSPHOLIPASE-A(2) AND ANTIINFLAMMATORY ACTIVITIES OF A UTEROGLOBIN FRAGMENT AND RELATED PEPTIDES, Arzneimittel-Forschung, 43-2(9), 1993, pp. 997-1000
Citations number
26
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
43-2
Issue
9
Year of publication
1993
Pages
997 - 1000
Database
ISI
SICI code
0004-4172(1993)43-2:9<997:SOTAAA>2.0.ZU;2-2
Abstract
The nonapeptide antiflammin P1 (H-Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser- OH), its isoAsp8 analogue and the corresponding aminosuccinyl peptide were prepared, characterized and tested for inhibition of phospholipas e A2 (PLA2) in vitro and for anti-inflammatory activity in vivo under assay conditions recently recommended. All peptides are devoid of PLA2 inhibitory and anti-inflammatory activity.