IN-VITRO ACTION OF NEW ORGANOMETALLIC COMPOUNDS AGAINST TRYPANOSOMATIDAE PROTOZOA

The effects of 10 newly synthesized organometalic rhodium complexes (5 of Rh (I), 4 of Rh (III) and one of Rh (IV) complex salt) and 2 antim ony (III) complexes against epimastigote forms of Trypanosoma cruzi an d promastigote forms of Leishmania donovani have been studied in vitro . Of the 10 rhodium complexes tested three proved 100% efficient in in hibiting the growth of the epimastigote forms of T. cruzi while only o ne worked against the promastigote forms of L. donovani. The two antim ony complexes inhibited the growth of L. donovani totally and were fai rly successful against T cruzi.