IN-VITRO ACTION OF NEW ORGANOMETALLIC COMPOUNDS AGAINST TRYPANOSOMATIDAE PROTOZOA

Citation
Cm. Mesavalle et al., IN-VITRO ACTION OF NEW ORGANOMETALLIC COMPOUNDS AGAINST TRYPANOSOMATIDAE PROTOZOA, Arzneimittel-Forschung, 43-2(9), 1993, pp. 1010-1013
Citations number
28
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
00044172
Volume
43-2
Issue
9
Year of publication
1993
Pages
1010 - 1013
Database
ISI
SICI code
0004-4172(1993)43-2:9<1010:IAONOC>2.0.ZU;2-4
Abstract
The effects of 10 newly synthesized organometalic rhodium complexes (5 of Rh (I), 4 of Rh (III) and one of Rh (IV) complex salt) and 2 antim ony (III) complexes against epimastigote forms of Trypanosoma cruzi an d promastigote forms of Leishmania donovani have been studied in vitro . Of the 10 rhodium complexes tested three proved 100% efficient in in hibiting the growth of the epimastigote forms of T. cruzi while only o ne worked against the promastigote forms of L. donovani. The two antim ony complexes inhibited the growth of L. donovani totally and were fai rly successful against T cruzi.