SYNTHESIS OF 4-AMINO HYDROXY-6-METHYLTHIO-1 2'-DIETHOXYETHYL)-1H/2H-PYRAZOLO[3,4-D]PYRIMIDINES AND THEIR ANTIALLERGIC ACTIVITY/

The synthesis of a series of 4-amino/hydroxy-6-substituted- 2'-diethox yethyl)-1H/2H-pyrazolo[3,4-d]pyrimidines by alkylation of substituted pyrazolo[3,4-d]pyrimidines has been described, and their antiallergic activity evaluated in mice. The 2 most active compounds 4b and 5b were also tested in the rat. The most active compound 4b showed non-signif icant antihistaminic or antiserotoninergic activity.