1,2-DIHYDROPYRIDINE DERIVATIVES AS POTENTIAL ANTIULCER AGENTS

Authors
DOMANY G MATUZ J SAGHY K EZER E
Citation
G. Domany et al., 1,2-DIHYDROPYRIDINE DERIVATIVES AS POTENTIAL ANTIULCER AGENTS, European journal of medicinal chemistry, 28(7-8), 1993, pp. 633-636
Citations number
8
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
28
Issue
7-8
Year of publication
1993
Pages
633 - 636
Database
ISI
SICI code
0223-5234(1993)28:7-8<633:1DAPAA>2.0.ZU;2-M
Abstract
Some 1-benzyl-2-cyanimino- and 1-benzyl-2-nitroimino-1,2-dihydropyridi nes were synthesized as new potential antiulcer agents. Some of these compounds exhibited significant antisecretory activity in the Shay tes t, like 1-(2-chlorobenzyl)-2-cyanimino-1,2-dihydropyridine (3c, ED50 = 1.8 mg/kg po), and some also had a cytoprotective effect, like 1-benz yl-2-cyanimino-1,2-dihydropyridine (3a, ED50 = 10.0 mg/kg po), in a mo dified Robert test, depending on the substitution of the benzyl group.