NOVEL THIOXOPYRIMIDINEDIONE DERIVATIVES - ANTIINFLAMMATORY AND ANALGESIC AGENTS

Authors
BHALLA M NAITHANI PK SRIVASTAVA VK BHALLA TN SHANKER K
Citation
M. Bhalla et al., NOVEL THIOXOPYRIMIDINEDIONE DERIVATIVES - ANTIINFLAMMATORY AND ANALGESIC AGENTS, European journal of medicinal chemistry, 28(7-8), 1993, pp. 643-646
Citations number
10
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
28
Issue
7-8
Year of publication
1993
Pages
643 - 646
Database
ISI
SICI code
0223-5234(1993)28:7-8<643:NTD-AA>2.0.ZU;2-O
Abstract
Some novel thioxopyrimidinedione derivatives have been synthesised and their anti-inflammatory activity in albino rats evaluated. Two compou nds (3, 5a) showing potent activity were further studied at graded dos es for their ED50 values. The LD50 values of the 2 compounds were dete rmined and they were shown to be devoid of ulcerogenic activity.