CLASS-I ASSOCIATIONS AND FREQUENCIES OF CLASS-II HLA-DRB ALLELES BY RFLP ANALYSIS IN CHILDREN WITH RHEUMATOID-FACTOR-NEGATIVE JUVENILE CHRONIC ARTHRITIS
Hi. Brunner et al., CLASS-I ASSOCIATIONS AND FREQUENCIES OF CLASS-II HLA-DRB ALLELES BY RFLP ANALYSIS IN CHILDREN WITH RHEUMATOID-FACTOR-NEGATIVE JUVENILE CHRONIC ARTHRITIS, Rheumatology international, 13(2), 1993, pp. 83-88
A total of 94 patients with juvenile chronic arthritis (JCA) was teste
d for HLA class I by serology and for class II by RFLP typing. Early o
nset JCA (EOPA) is associated with HLA-A2, DR5 and DR8 in both males a
nd females. The combination (joint occurrence) of these JCA associated
alleles (A2, DR5, DR8) is frequently seen in patients with chronic ir
idocyclitis. Late onset pauciarticular disease has an increased freque
ncy of HLA-B27, especially in males. Our data confirm that polyarticul
ar JCA with early childhood onset (less-than-or-equal-to 4 years) is a
ssociated with DR5 and DR8 and has a different immunogenetic backgroun
d from polyarticular JCA with later childhood (>4 years) onset (associ
ated with DR4).