Gt. Panse et al., A SPECIFIC AND RAPID RECEPTOR ASSAY FOR SQUAMOUS-CELL CARCINOMA OF HUMAN ESOPHAGUS, Journal of cancer research and clinical oncology, 119(12), 1993, pp. 734-736
A specific radioreceptor assay, for squamous-cell carcinoma of the hum
an esophagus, using 2G3 monoclonal antibody, has been developed for th
e first time. In this assay a new mathematical parameter of the Scatch
ard plot has been introduced for the correct measure of binding capaci
ty (BC(cm) = x cos alpha). This is the perpendicular distance from the
origin to the Scatchard plot line. It is always a positive quantity a
nd is directly proportional to both the x and y intercepts for express
ing the binding capacity. The assay is highly sensitive and can be use
d to differentiate various types of esophageal tumors such as squamous
-cell carcinoma, adenocarcinoma, ulcerative growth and also a benign g
rowth. BC(cm) significantly varies in the case of squamous-cell carcin
oma tumors compared to adenocarcinoma and other types of tumor of the
human esophagus. The assay can be completed in about 4 h and it may be
used as a clinical diagnostic test.