Ag. Gharavi et al., RESTING DIASTOLIC FUNCTION AND LEFT-VENTRICULAR MASS ARE RELATED TO EXERCISE CAPACITY IN HYPERTENSIVE MEN BUT NOT IN WOMEN, American journal of hypertension, 11(10), 1998, pp. 1252-1257
We evaluated the impact of diastolic function and gender on exercise c
apacity in sedentary, untreated hypertensive subjects (34 men, 23 wome
n) using echocardiography and a bicycle ergometry with measurement of
oxygen consumption (VO2). In men, peak (A) mitral inflow velocity and
left ventricular (LV) mass were inversely related to peak VO2 (r = -0.
64) and maximal workload (r = -0.57) and were the sole independent det
erminants of exercise capacity. In women, there was no relationship be
tween any echocardiographic measure and exercise capacity. Thus, LV ma
ss and Doppler-determined diastolic function predict maximal VO2 in hy
pertensive men but not in women. This finding may be related to gender
differences in the contribution of diastolic filling to exercise capa
city or may reflect limitations of resting Doppler echocardiography to
predict exercise diastolic filling in hypertensive women. Am J Hypert
ens 1998;11:1252-1257 (C) 1998 American Journal of Hypertension, Ltd.