A RANDOMIZED COMPARISON OF DILATATION ALONE VERSUS DILATATION PLUS LASER IN PATIENTS RECEIVING CHEMOTHERAPY AND EXTERNAL-BEAM RADIATION FORESOPHAGEAL-CARCINOMA
Bs. Anand et al., A RANDOMIZED COMPARISON OF DILATATION ALONE VERSUS DILATATION PLUS LASER IN PATIENTS RECEIVING CHEMOTHERAPY AND EXTERNAL-BEAM RADIATION FORESOPHAGEAL-CARCINOMA, Digestive diseases and sciences, 43(10), 1998, pp. 2255-2260
Most patients with carcinoma of the esophagus have advanced disease at
presentation. Since cure is usually not possible, the goal of treatme
nt is the palliation of dysphagia. Palliative modalities include bougi
es, balloons, stents, tumor probe, laser, surgery, chemotherapy, and r
adiation. In recent years, combined chemotherapy and radiation has sho
wn promising results. However, the relief of dysphagia is slow and fre
quently incomplete. We compared the effectiveness of dilatation alone
versus dilatation plus Nd-YAG laser therapy for the relief of dysphagi
a while assessing the role of chemotherapy and radiation as an adjunct
to surgery. Fifteen patients with squamous cell carcinoma of esophagu
s who were deemed fit for intensive chemotherapy and radiation were ra
ndomized to receive either dilatation alone (N = 7) or dilatation plus
laser (N = 8); the end-point for initial success was the passage of a
45 French Savary dilator, and the relief of dysphagia. At entry, 13 o
f these 15 patients were judged potentially resectable. However, after
chemotherapy and radiation, only 3 of 13 (20%) patients could be offe
red surgery; the remainder were considered too poor a surgical risk. F
ollow-up was for 30 months, or until death. Further dilatations were p
erformed as needed for relief of dysphagia. No difference was observed
between the laser plus dilatation and the dilatation alone group with
respect to the degree of dysphagia, weight record, quality of life in
dex (Karnofsky score), or mortality rate. Our results indicate that in
patients undergoing chemotherapy and radiation for esophageal carcino
ma, dilatation alone provides adequate palliation of dysphagia, and in
these patients, chemotherapy and radiation is a poor adjunct to surgi
cal treatment.