MICROFLORA OF GASTRIC BIOPSIES FROM PATIENTS WITH DUODENAL-ULCER AND GASTRIC-CANCER - A COMPARATIVE-STUDY OF PATIENTS FROM KOREA, COLOMBIA,AND THE UNITED-STATES

It remains unclear why the spectrum of H, pylori-related diseases diff ers among different geographic regions. We examined the non-H, pylori contamination rates of the stomach in patients with duodenal ulcer or gastric adenocarcinoma from three different regions with different spe ctra of H. pylori-related diseases. Gastric biopsies were cultured fro m patients with duodenal ulcer or histologically proven gastric cancer from Seoul, Korea; Bogota, Colombia; and Houston, Texas. The frequenc y of non-H. pylori contamination was tallied in relation to the clinic al diagnosis. Cultures from 247 duodenal ulcer patients and 165 patien ts with gastric cancer had bacterial growth. H. pylori was isolated fr om 207 (73.7%) patients with duodenal ulcer and 90 (47.1%) patients wi th gastric cancer (P < 0.001), In patients with duodenal ulcer (DU) or gastric cancer (GC), the rate of positive cultures for H, pylori were not statistically different (P > 0.143 for DU, P > 0.190 for GC) betw een regions. The frequency of isolation ranged from 69% to 79% for DU patients and from 39% to 50% for gastric cancer patients. Non-H, pylor i bacterial contamination was found more frequently (63%) in Colombian duodenal ulcer patients compared to 30% ulcer patients from the Unite d States or Korea (P < 0.001). Non-H. pylori growth occurred in 50.8-7 5.5% of cancer patients and was significantly lower in US patients tha n in patients from either Colombia or Korea (P < 0.01). The geographic location as well as disease status affects the rate of H, pylori reco very and non-H. pylori contamination of the stomach and may play a rol e in the geographic differences in manifestation of H. pylori infectio n. The fact that the proportion of gastric cancer patients in the Unit ed States with non-H, pylori contamination was significantly less than that of Korea or Colombia shows that the notion of an almost universa l increase in gastric microbial content in gastric adenocarcinoma shou ld be reconsidered.