M. Kaljurand et Hc. Smit, MONITORING OF RANDOMLY VARYING CHEMICAL PROCESSES BY CORRELATION CHROMATOGRAPHY, Analytica chimica acta, 373(2-3), 1998, pp. 175-187
Correlation chromatography (CC) is a well known method for reducing de
tection limits in chromatographic analysis. Its usefulness for the mon
itoring of varying substance flows is however more ambiguous. Although
generally believed as a useful tool for this purpose, very little wor
k has been done to prove it. In this paper CC and common, single injec
tion chromatography (SIC) were compared with respect to their restorat
ion capabilities of a stochastic first order process, which is assumed
to be the varying concentration input function of a chromatograph. It
is demonstrated that CC can restore the input function with a smaller
error than SIC when the process rate and input sequence length are re
lated by a certain condition. The effect was found to be more profound
when measurement noise is present due to the multiplex advantage of t
he CC method. (C) 1998 Elsevier Science B.V. All rights reserved.