SYNTHESIS OF ENANTIOMERIC SELECTIVE ALPHA(1)-ACID GLYCOPROTEIN (AGP)-BONDED CAPILLARY AND ITS APPLICATION IN CAPILLARY-ELECTROPHORESIS

alpha(1)-Acid glycoprotein (AGP) was bonded to a fused silica capillar y using 3-(2,3-oxopropoxypropyl, trimethylsilane as bridging reagent. The capillary can be used for the direct enantiomeric separation of so me basic pharmaceuticals in capillary zone electrophoresis. The relate d operation parameters such as pH, salt concentration, organic modifie rs in the buffer have been studied. It is demonstrated that an AGP-bon ded capillary could be used in the different buffer solutions and unde r operation conditions in capillary electrophoresis with good stabilit y. (C) 1998 Elsevier Science B.V. All rights reserved.