GLUTATHIONE TRANSFERASE T1 AND M1 GENOTYPE POLYMORPHISM IN THE NORMALPOPULATION OF SHANGHAI

Glutathione transferases are known to be important enzymes in the meta bolism of xenobiotics. In humans genetic polymorphisms have been repor ted for the hGSTM1 and hGSTT1 genes leading to individual differences in susceptibility towards toxic effects, such as cancer. This study de scribes the distribution of the two polymorphisms of hGSTT1 and hGSTM1 in the normal Chinese population of Shanghai. Out of 219 healthy indi viduals having been genotyped for GSTT1 and GSTM1, 108 (49%) were iden tified to be homozygously deficient for the GSTT1 gene and 107 (49%) f or the GSTM1 gene.