PREPARATION AND DIASTEREOSELECTIVE FUNCTIONALIZATION OF A NEW CHIRAL NON RACEMIC BICYCLIC HYDRAZINOLACTAM

Authors
ROUSSI F BONIN M CHIARONI A MICOUIN L RICHE C HUSSON HP
Citation
F. Roussi et al., PREPARATION AND DIASTEREOSELECTIVE FUNCTIONALIZATION OF A NEW CHIRAL NON RACEMIC BICYCLIC HYDRAZINOLACTAM, Tetrahedron letters, 39(44), 1998, pp. 8081-8084
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
44
Year of publication
1998
Pages
8081 - 8084
Database
ISI
SICI code
0040-4039(1998)39:44<8081:PADFOA>2.0.ZU;2-E
Abstract
Starting with R-(-)-phenylglycinol, the synthesis of a new bicyclic hy drazinolactam 3 was realized on a multigram scale. The reaction scope of the corresponding enolate with various electrophiles has been studi ed. Good to excellent diastereoselectivities were obtained. (C) 1998 P ublished by Elsevier Science Ltd. All rights reserved.